Evaluation of therapeutically induced hypertension in patients with delayed cerebral vasospasm by xenon-enhanced computed tomography

Neurol Med Chir (Tokyo). 1992 Aug;32(9):671-8. doi: 10.2176/nmc.32.671.

Abstract

Serial cerebral blood flow (CBF) measurements were made with stable xenon-enhanced computed tomography in 20 patients with angiographically confirmed ruptured intracranial aneurysms, before and during induced hypertension with continuous infusion of dopamine. All patients showed angiographic vasospasm during their course. Twelve patients without symptomatic vasospasm (Group 1) had the lowest hemispheric CBF on the craniotomy side of 31.6 +/- 6.8 ml/100 gm/min on days 4-9 (control value, 40.1 +/- 2.0 ml/100 gm/min), while the other eight patients with symptomatic vasospasm (Group 2) had the lowest hemispheric CBF on the craniotomy side of 25.0 +/- 7.6 ml/100 gm/min on days 10-14. The critical hemispheric CBF inducing neurological deficits was about 20 ml/100 gm/min in Group 2. Dysautoregulation was usually present in Groups 1 and 2, but therapeutically induced hypertension could reverse the delayed neurological deficits, if begun early at the stage of delayed vasospasm.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Blood Pressure / drug effects*
  • Cerebrovascular Circulation
  • Dopamine / therapeutic use*
  • Humans
  • Ischemic Attack, Transient / diagnostic imaging
  • Ischemic Attack, Transient / physiopathology
  • Ischemic Attack, Transient / therapy*
  • Middle Aged
  • Tomography, X-Ray Computed*
  • Xenon*

Substances

  • Xenon
  • Dopamine