Abstract
The synthesis of phenothiazine and anthraquinone derivatives, bearing at least one fragment present in lotifazole, is reported. Some of the new compounds showed antitumor activity in vitro (P388 leukemia cells) and in vivo (Ehrlich ascites tumor cells in mice).
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
-
Anti-Inflammatory Agents, Non-Steroidal / pharmacology
-
Antineoplastic Agents / chemical synthesis*
-
Antineoplastic Agents / pharmacology
-
Carbamates / chemical synthesis*
-
Carbamates / pharmacology
-
Carcinoma, Ehrlich Tumor / drug therapy
-
Female
-
Leukemia P388 / drug therapy
-
Mice
-
Polycyclic Compounds / chemical synthesis*
-
Polycyclic Compounds / pharmacology
-
Tumor Cells, Cultured
Substances
-
Anti-Inflammatory Agents, Non-Steroidal
-
Antineoplastic Agents
-
Carbamates
-
Polycyclic Compounds
-
lotifazole