Abstract
Growth of the human squamous cervical carcinoma cell line, HOG-I, was stimulated in response to oestradiol in serum-containing and chemically defined medium. The oestradiol-stimulated growth could be inhibited by 4-OH tamoxifen, progesterone and medroxyprogesterone acetate; the last 2 compounds also inhibited basal cell growth in serum-containing and chemically defined media. The data are consistent with the sensitivity of human squamous cervical cancer to sex-steroid hormones and suggest that endocrine therapies may be of benefit in this disease.
MeSH terms
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Adult
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Carcinoma, Squamous Cell / chemistry
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Carcinoma, Squamous Cell / drug therapy*
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Carcinoma, Squamous Cell / pathology
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Cell Division / drug effects
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Culture Media
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Estradiol / pharmacology*
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Female
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Humans
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Medroxyprogesterone / analogs & derivatives*
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Medroxyprogesterone / pharmacology
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Medroxyprogesterone Acetate
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Tamoxifen / analogs & derivatives*
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Tamoxifen / pharmacology*
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Tumor Cells, Cultured
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Uterine Cervical Neoplasms / chemistry
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Uterine Cervical Neoplasms / drug therapy*
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Uterine Cervical Neoplasms / pathology
Substances
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Culture Media
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Tamoxifen
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afimoxifene
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Estradiol
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Medroxyprogesterone Acetate
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Medroxyprogesterone