Synthesis and antihypertensive activity of imidazo[2,1-b]-thiazoles bearing a 2,6-dichlorophenyl group

A Andreani; M Rambaldi; A Locatelli; A Cristoni; S Malandrino; G Pifferi

Synthesis and antihypertensive activity of imidazo[2,1-b]-thiazoles bearing a 2,6-dichlorophenyl group

Acta Pharm Nord. 1992;4(2):93-6.

Authors

A Andreani¹, M Rambaldi, A Locatelli, A Cristoni, S Malandrino, G Pifferi

Affiliation

¹ Dipartimento di Scienze Farmaceutiche, University of Bologna, Italy.

PMID: 1388775

Abstract

A number of imidazo[2,1-b]thiazoles bearing a 2,6-dichlorophenyl group as hydrazone or as amide were prepared and tested in rats as antihypertensive agents. Only compounds bearing a chlorine at position 6 were active.

MeSH terms

Administration, Oral
Animals
Antihypertensive Agents / chemical synthesis*
Antihypertensive Agents / pharmacology
Blood Pressure / drug effects*
Imidazoles / administration & dosage
Imidazoles / chemical synthesis*
Imidazoles / pharmacology
Male
Rats
Rats, Inbred SHR
Thiazoles / administration & dosage
Thiazoles / chemical synthesis*
Thiazoles / pharmacology

Substances

Antihypertensive Agents
Imidazoles
Thiazoles