Abstract
The concentrated Perflubron emulsion, Oxygent, in combination with breathing a 95% oxygen atmosphere, significantly enhanced the response of the murine Lewis lung carcinoma to fractionated radiation therapy. Administration of 4 to 12 g PFC/kg was most effective if administered prior to each x-ray fraction, however, alternated day and even once weekly administration of 8 or 12 PFC/kg and 95% oxygen breathing with each x-ray fraction resulted in significant improvements in tumor growth delay.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Blood Substitutes / administration & dosage
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Blood Substitutes / therapeutic use*
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Carbon Dioxide
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Combined Modality Therapy
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Drug Administration Schedule
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Emulsions
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Fluorocarbons / administration & dosage
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Fluorocarbons / therapeutic use*
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Hydrocarbons, Brominated
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Lung Neoplasms / radiotherapy
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Lung Neoplasms / therapy*
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Male
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Mice
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Mice, Inbred C57BL
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Oxygen
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Radiation-Sensitizing Agents / administration & dosage
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Radiation-Sensitizing Agents / therapeutic use*
Substances
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Blood Substitutes
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Emulsions
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Fluorocarbons
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Hydrocarbons, Brominated
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Radiation-Sensitizing Agents
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Carbon Dioxide
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carbogen
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perflubron
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Oxygen