Abstract
Diels-Alder heterocycloaddition reactions of 2,5,8-quinolinetriones and 1-azadienes afford 1,8-diaza-2,9,10-anthracenetriones, which are simple analogues of the antitumoral antibiotic diazaquinomicin A. Cytotoxicity in this series and antitumor activity of the lead compound, 6-methyl-1,8-diaza-2,9,10-anthracenetrione, are reported.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Anthracenes / chemical synthesis*
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Anthracenes / pharmacology
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Drug Screening Assays, Antitumor
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HeLa Cells
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Humans
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Quinones / pharmacology
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Tumor Cells, Cultured / drug effects
Substances
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Anthracenes
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Antineoplastic Agents
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Quinones
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diazaquinomycin A