Abstract
The synthesis of three series of new imidazo [2,1-b] thiazoles (nitriles 1-7, amides 8-14 and p-sulfamidophenylhydrazones 15-24) is reported. Among the compounds tested, only 12 showed a borderline diuretic activity. Compounds 15-24, possible prodrugs of sulfanilamide, were devoid of antibacterial activity.
MeSH terms
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Amides / chemical synthesis*
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Amides / pharmacology
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Animals
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / pharmacology
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Bacteria / drug effects
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Diuretics / chemical synthesis*
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Diuretics / pharmacology
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Hydrazones / chemical synthesis*
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Hydrazones / pharmacology
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Imidazoles / chemical synthesis*
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Imidazoles / pharmacology
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Male
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Microbial Sensitivity Tests
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Nitriles / chemical synthesis*
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Nitriles / pharmacology
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Rats
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Rats, Sprague-Dawley
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Thiazoles / chemical synthesis*
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Thiazoles / pharmacology
Substances
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Amides
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Anti-Bacterial Agents
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Diuretics
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Hydrazones
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Imidazoles
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Nitriles
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Thiazoles