Impact of imipenem/cilastatin on cyclosporine metabolism and excretion

Transplant Proc. 1992 Oct;24(5):1704-8.
No abstract available

MeSH terms

  • Animals
  • Bile / drug effects
  • Bile / metabolism
  • Cilastatin / pharmacology*
  • Cyclosporine / metabolism*
  • Cyclosporine / pharmacokinetics
  • Cytosol / metabolism
  • Imipenem / pharmacology*
  • Ketoconazole / pharmacology
  • Liver / drug effects
  • Liver / metabolism*
  • Male
  • Phenobarbital / pharmacology
  • Rats
  • Rats, Inbred Strains
  • Time Factors

Substances

  • Cilastatin
  • Imipenem
  • Cyclosporine
  • Ketoconazole
  • Phenobarbital