Abstract
In an attempt to understand more completely why patients treated with phenothiazines (chlorpromazine and cyamemazine), methotrexate, and certain antibiotics such as clindamycin have an increased risk of developing pseudomembranous colitis, the production of toxins A and B by Clostridium difficile in the presence of these drugs was measured in vitro as well as in vivo by using axenic mice. None of the drugs tested increased the production of toxins either in vitro or in vivo.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Anti-Bacterial Agents / pharmacology*
-
Bacterial Proteins*
-
Bacterial Toxins / biosynthesis*
-
CHO Cells
-
Clostridioides difficile / drug effects
-
Clostridioides difficile / metabolism*
-
Clostridium Infections / metabolism
-
Clostridium Infections / microbiology
-
Cricetinae
-
Enterotoxins / biosynthesis*
-
Enzyme-Linked Immunosorbent Assay
-
Feces / chemistry
-
Feces / microbiology
-
Mice
-
Mice, Inbred C3H
Substances
-
Anti-Bacterial Agents
-
Bacterial Proteins
-
Bacterial Toxins
-
Enterotoxins
-
tcdA protein, Clostridium difficile
-
toxB protein, Clostridium difficile