Abstract
Foscarnet and zidovudine (ZDV) pharmacokinetic parameters were not altered in five patients receiving 14 days of concomitant therapy. Foscarnet clearance in plasma averaged (+/- standard deviation) 0.16 +/- 0.03 and 0.13 +/- 0.05 liter/h/kg of body weight in the absence and presence of ZDV. ZDV parameters were also not significantly altered, with a mean (+/- standard deviation) oral clearance of 2.7 +/- 1.0 and 2.6 +/- 0.8 liter/h/kg for the 2 study days, respectively.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acquired Immunodeficiency Syndrome / drug therapy
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Acquired Immunodeficiency Syndrome / metabolism*
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Adult
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Antiviral Agents / pharmacokinetics*
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Antiviral Agents / therapeutic use
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Chromatography, High Pressure Liquid
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Drug Interactions
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Foscarnet / pharmacokinetics*
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Foscarnet / therapeutic use
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HIV Core Protein p24 / analysis
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HIV Core Protein p24 / immunology
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Humans
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Male
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Middle Aged
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Zidovudine / pharmacokinetics*
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Zidovudine / therapeutic use
Substances
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Antiviral Agents
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HIV Core Protein p24
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Foscarnet
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Zidovudine