Abstract
The synthesis of various pyrrylphenylethanones resembling cathinone and lefetamine is described starting from 2-chloro-1-(1-methyl-1H-pyrrol-2-yl)-2-phenylethan-1-one. Some derivatives showed good antinociceptic activity, comparable to that of morphine. The neuropsychopharmacological profile of title compounds has been also studied to explore their action on C.N.S.
MeSH terms
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Alkaloids / chemistry*
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Analgesics / chemical synthesis
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Analgesics / pharmacology
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Animals
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Anticonvulsants / chemical synthesis
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Anticonvulsants / pharmacology
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Behavior, Animal / drug effects
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Female
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Ketones / chemical synthesis*
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Ketones / pharmacology
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Male
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Mice
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Muscle Relaxants, Central / chemical synthesis
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Muscle Relaxants, Central / pharmacology
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Phenethylamines / chemistry*
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Psychotropic Drugs / chemical synthesis*
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Psychotropic Drugs / pharmacology
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Pyrroles / chemical synthesis*
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Pyrroles / pharmacology
Substances
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Alkaloids
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Analgesics
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Anticonvulsants
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Ketones
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Muscle Relaxants, Central
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Phenethylamines
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Psychotropic Drugs
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Pyrroles
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lephetamine
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cathinone