Abstract
A series of furazanyl- and furoxanyl-1,4-dihydropyridines has been synthesized and tested for their cardiovascular activity. The new compounds showed a modest activity in comparison with nifedipine and some selectivity for the myocardial muscle. The most active compound was diethyl 1,4-dihydro-2,6-dimethyl-4-(3-phenyl-4-furoxanyl)-3,5-pyridine dicarboxylate, 4d.
MeSH terms
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Animals
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Aorta, Thoracic / drug effects
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Calcium Channel Blockers / pharmacology
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Cardiovascular Agents / chemical synthesis*
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Cardiovascular Agents / pharmacology
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Dihydropyridines / chemical synthesis*
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Dihydropyridines / pharmacology
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Female
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Guinea Pigs
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Heart Rate / drug effects
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Heterocyclic Compounds / chemical synthesis*
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Heterocyclic Compounds / pharmacology
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In Vitro Techniques
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Magnetic Resonance Spectroscopy
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Male
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Muscle Contraction / drug effects
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Muscle, Smooth, Vascular / drug effects
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Myocardial Contraction / drug effects
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Nifedipine / pharmacology
Substances
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Calcium Channel Blockers
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Cardiovascular Agents
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Dihydropyridines
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Heterocyclic Compounds
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Nifedipine