False-positive elevation of CA-125 in papillary serous carcinoma of the endometrium treated with postoperative whole abdominal radiation

Gynecol Oncol. 1992 Oct;47(1):127-9. doi: 10.1016/0090-8258(92)90088-z.

Abstract

Two patients with Stage I papillary serous carcinoma of the endometrium treated with postoperative whole abdominal radiation developed elevated CA-125 levels. In neither patient was evidence of recurrent disease identified. Hepatic veno-occlusive disease, a known complication of whole abdominal radiation and certain chemotherapy regimens, was confirmed by liver biopsy in both cases. CA-125 levels may not be reflective of disease status in this setting.

Publication types

  • Case Reports

MeSH terms

  • Abdomen / radiation effects*
  • Antigens, Tumor-Associated, Carbohydrate / analysis*
  • Biopsy
  • Carcinoma, Papillary / epidemiology
  • Carcinoma, Papillary / immunology*
  • Carcinoma, Papillary / radiotherapy*
  • Endometrial Neoplasms / epidemiology
  • Endometrial Neoplasms / immunology*
  • Endometrial Neoplasms / radiotherapy*
  • False Positive Reactions
  • Female
  • Follow-Up Studies
  • Hepatic Veno-Occlusive Disease / diagnosis
  • Hepatic Veno-Occlusive Disease / etiology
  • Hepatic Veno-Occlusive Disease / pathology
  • Humans
  • Liver / pathology
  • Middle Aged
  • Radiation Injuries / complications
  • Radiation Injuries / diagnosis
  • Radiation Injuries / pathology

Substances

  • Antigens, Tumor-Associated, Carbohydrate