Insulin and growth factors adaptation to normal puberty

M O Savage; C P Smith; D B Dunger; E A Gale; J M Holly; M A Preece

doi:10.1159/000182405

Insulin and growth factors adaptation to normal puberty

Horm Res. 1992:37 Suppl 3:70-3. doi: 10.1159/000182405.

Authors

M O Savage¹, C P Smith, D B Dunger, E A Gale, J M Holly, M A Preece

Affiliation

¹ Department of Endocrinology, St. Bartholomew's Hospital, London, UK.

PMID: 1427646
DOI: 10.1159/000182405

Abstract

Insulin and IGF-1 production were measured throughout childhood and puberty and into adult life. Basal insulin and IGF-1 secretion increased during puberty, falling back to prepubertal levels in adulthood. However, fasting glucose levels remained constant, implying an increase in tissue resistance to insulin coinciding with puberty.

MeSH terms

Adaptation, Physiological
Adolescent
Adult
Blood Glucose / metabolism
Child
Child, Preschool
Female
Growth Hormone / metabolism
Humans
Insulin / blood*
Insulin / metabolism
Insulin Resistance / physiology
Insulin Secretion
Insulin-Like Growth Factor I / biosynthesis*
Insulin-Like Growth Factor I / metabolism
Male
Puberty / physiology*
Reference Values

Substances

Blood Glucose
Insulin
Insulin-Like Growth Factor I
Growth Hormone