Linkage heterogeneity between the C3 and LDLR and the APOA4 and APOA1 loci in baboons

Genomics. 1992 Sep;14(1):43-8. doi: 10.1016/s0888-7543(05)80281-2.

Abstract

We detected linkage in baboons between loci for the third component of complement (C3) and the low-density lipoprotein receptor (LDLR), lod score = 5.53, and loci for apolipoprotein A1 (APOA1) and apolipoprotein AIV (APOA4), lod score = 14.59. We also found evidence for linkage heterogeneity among the baboon pedigrees between LDLR and C3 (P = 0.04) and between APOA1 and APOA4 (P = 0.01).

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Apolipoprotein A-I / genetics*
  • Apolipoproteins A / genetics*
  • Complement C3 / genetics*
  • Female
  • Genetic Linkage*
  • Genetic Markers
  • Lod Score
  • Male
  • Papio / genetics*
  • Receptors, LDL / genetics*
  • Recombination, Genetic

Substances

  • Apolipoprotein A-I
  • Apolipoproteins A
  • Complement C3
  • Genetic Markers
  • Receptors, LDL
  • apolipoprotein A-IV