Antifungal cyclic peptides from the terrestrial blue-green alga Anabaena laxa. I. Isolation and biological properties

W P Frankmölle; L K Larsen; F R Caplan; G M Patterson; G Knübel; I A Levine; R E Moore

doi:10.7164/antibiotics.45.1451

Antifungal cyclic peptides from the terrestrial blue-green alga Anabaena laxa. I. Isolation and biological properties

J Antibiot (Tokyo). 1992 Sep;45(9):1451-7. doi: 10.7164/antibiotics.45.1451.

Authors

W P Frankmölle¹, L K Larsen, F R Caplan, G M Patterson, G Knübel, I A Levine, R E Moore

Affiliation

¹ Department of Chemistry, University of Hawaii, Honolulu 96822.

PMID: 1429231
DOI: 10.7164/antibiotics.45.1451

Abstract

Laxaphycins are responsible for the antifungal and cytotoxic activity of crude ethanolic extracts from the cultured blue-green alga Anabaena laxa. These cyclic peptides exhibit an unusual biological synergism when tested for antifungal or cytotoxic effects. The isolation procedure for the peptides, their characterization and biological activities are described here along with experiments demonstrating synergism between the two major laxaphycins.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Antifungal Agents / chemistry
Antifungal Agents / isolation & purification*
Antifungal Agents / pharmacology
Chromatography, High Pressure Liquid
Cyanobacteria / chemistry*
Drug Synergism
Fungi / drug effects*
Microbial Sensitivity Tests
Peptides, Cyclic / chemistry
Peptides, Cyclic / isolation & purification*
Peptides, Cyclic / pharmacology

Substances

Antifungal Agents
Peptides, Cyclic