Design and synthesis of a C7 mimetic for the predicted gamma-turn conformation found in several constrained RGD antagonists

J Med Chem. 1992 Oct 16;35(21):3970-2. doi: 10.1021/jm00099a027.
No abstract available

MeSH terms

  • Amino Acid Sequence
  • Drug Design
  • Fibrinogen / metabolism
  • Magnetic Resonance Spectroscopy
  • Molecular Sequence Data
  • Oligopeptides / chemistry*
  • Oligopeptides / metabolism
  • Peptides, Cyclic / chemical synthesis
  • Peptides, Cyclic / chemistry*
  • Peptides, Cyclic / metabolism
  • Platelet Aggregation Inhibitors / metabolism
  • Platelet Membrane Glycoproteins / antagonists & inhibitors
  • Platelet Membrane Glycoproteins / metabolism
  • Protein Conformation

Substances

  • Oligopeptides
  • Peptides, Cyclic
  • Platelet Aggregation Inhibitors
  • Platelet Membrane Glycoproteins
  • arginyl-glycyl-aspartic acid
  • Fibrinogen