Abstract
Sodium nitroprusside, nitroglycerin and carperitide (alpha-human ANP) all reduced mean blood pressure, but only carperitide increased the hematocrit in rats with bilateral renal artery- and ureter-ligation. NG-Monomethyl-L-arginine, a selective inhibitor of nitric oxide synthesis, elevated the mean blood pressure but did not change the hematocrit significantly. These findings suggest that ANP has a physiological role in regulating circulatory blood volume distinct from that of NO, although both increase intracellular cyclic GMP in the vasculature.
MeSH terms
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Anesthesia
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Animals
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Arginine / analogs & derivatives
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Arginine / pharmacology
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Atrial Natriuretic Factor / pharmacology*
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Blood Pressure / drug effects
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Erythrocytes / drug effects*
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Heart Rate / drug effects
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Hematocrit
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Hemodynamics / drug effects*
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Male
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Nitric Oxide / metabolism
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Nitric Oxide / pharmacology*
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Nitroglycerin / pharmacology
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Nitroprusside / pharmacology
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Peptide Fragments / pharmacology*
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Rats
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Rats, Wistar
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Recombinant Proteins / pharmacology
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omega-N-Methylarginine
Substances
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Peptide Fragments
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Recombinant Proteins
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Nitroprusside
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omega-N-Methylarginine
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Nitric Oxide
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Atrial Natriuretic Factor
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Arginine
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Nitroglycerin