Abstract
CSF hypocretin-1 was measured in 28 Guillain-Barré syndrome (GBS), 12 Miller-Fisher syndrome, 12 chronic inflammatory demyelinating polyneuropathy (CIDP), and 48 control subjects. Seven GBS subjects had undetectably low hypocretin-1 levels (<100 pg/mL). Hypocretin-1 levels were moderately reduced in an additional 11 GBS, 5 Miller-Fisher syndrome, and 1 CIDP subject. Low levels in GBS occurred early in the disease and were associated with upper CNS level abnormalities.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adolescent
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Adult
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Aged
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Carrier Proteins / cerebrospinal fluid*
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Female
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Guillain-Barre Syndrome / cerebrospinal fluid*
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Guillain-Barre Syndrome / complications
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Humans
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Intracellular Signaling Peptides and Proteins*
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Male
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Middle Aged
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Miller Fisher Syndrome / cerebrospinal fluid*
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Neuropeptides / cerebrospinal fluid*
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Neuropeptides / deficiency
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Orexins
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Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / cerebrospinal fluid*
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Quadriplegia / cerebrospinal fluid
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Quadriplegia / etiology
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Single-Blind Method
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Sleep Wake Disorders / cerebrospinal fluid
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Sleep Wake Disorders / etiology
Substances
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Carrier Proteins
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HCRT protein, human
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Intracellular Signaling Peptides and Proteins
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Neuropeptides
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Orexins