Biophysical model of synaptic plasticity dynamics

Henry D I Abarbanel; Leif Gibb; R Huerta; M I Rabinovich

doi:10.1007/s00422-003-0422-x

Biophysical model of synaptic plasticity dynamics

Biol Cybern. 2003 Sep;89(3):214-26. doi: 10.1007/s00422-003-0422-x. Epub 2003 Jul 31.

Authors

Henry D I Abarbanel¹, Leif Gibb, R Huerta, M I Rabinovich

Affiliation

¹ Institute for Nonlinear Science, Center for Theoretical Biological Physics, Marine Physical Laboratory (Scripps Institution of Oceanography) and Department of Physics, University of California, San Diego, La Jolla, CA 93093-0402, USA. [email protected]

PMID: 14504940
DOI: 10.1007/s00422-003-0422-x

Abstract

We discuss a biophysical model of synaptic plasticity that provides a unified view of the outcomes of synaptic modification protocols, including: (1) prescribed time courses of postsynaptic intracellular Ca(2+) release, (2) postsynaptic voltage clamping with presentation of presynaptic spike trains at various frequencies, (3) direct postsynaptic response to presynaptic spike trains at various frequencies, and (4) LTP/LTD as a response to precisely timed presynaptic and postsynaptic spikes.

Publication types

Comparative Study

MeSH terms

Animals
Calcium / metabolism
Calcium Channels / physiology
Dose-Response Relationship, Drug
Electric Stimulation
Excitatory Postsynaptic Potentials
Hippocampus / drug effects
Hippocampus / physiology
Magnesium / pharmacology
Models, Biological*
Neuronal Plasticity / physiology*
Neurons / drug effects
Neurons / physiology
Nonlinear Dynamics*
Presynaptic Terminals / physiology
Reaction Time / physiology
Receptors, AMPA / physiology
Receptors, N-Methyl-D-Aspartate / physiology
Synapses / drug effects
Synapses / physiology*
Synaptic Transmission
Time Factors

Substances

Calcium Channels
Receptors, AMPA
Receptors, N-Methyl-D-Aspartate
Magnesium
Calcium