Glucose-lowering in a db/db mouse model by dihydropyridine diacid glycogen phosphorylase inhibitors

Bioorg Med Chem Lett. 2003 Oct 20;13(20):3405-8. doi: 10.1016/s0960-894x(03)00798-4.

Abstract

The synthesis of a series of novel dihdyropyridine diacid glycogen phosphorylase inhibitors is presented. SAR and functional assay data are discussed, along with the effect of a single inhibitor on blood glucose in a diabetic animal model.

MeSH terms

  • Animals
  • Blood Glucose / analysis*
  • Diabetes Mellitus, Experimental / drug therapy
  • Dihydropyridines / chemistry*
  • Disease Models, Animal
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Enzyme Inhibitors / therapeutic use
  • Glycogen Phosphorylase / antagonists & inhibitors*
  • Hypoglycemic Agents / chemistry
  • Hypoglycemic Agents / pharmacology*
  • Hypoglycemic Agents / therapeutic use
  • Mice

Substances

  • Blood Glucose
  • Dihydropyridines
  • Enzyme Inhibitors
  • Hypoglycemic Agents
  • 1,4-dihydropyridine
  • Glycogen Phosphorylase