Association between HLA class I antigens and response to interferon therapy in children with chronic HBV hepatitis

R Giacchino; A Nocera; A Timitilli; E Cristina; G Giambartolomei; F Caocci; C Cirillo; S Barocci

doi:10.1007/978-3-7091-5633-9_63

Association between HLA class I antigens and response to interferon therapy in children with chronic HBV hepatitis

Arch Virol Suppl. 1992:4:281-3. doi: 10.1007/978-3-7091-5633-9_63.

Authors

R Giacchino¹, A Nocera, A Timitilli, E Cristina, G Giambartolomei, F Caocci, C Cirillo, S Barocci

Affiliation

¹ I Clinica Malattie Infettive, Università di Genova, Italy.

PMID: 1450702
DOI: 10.1007/978-3-7091-5633-9_63

Abstract

In this preliminary study, children with chronic HBV hepatitis, as was also previously shown for adults, respond to interferon therapy in an HLA class I antigen dependent manner. If this can be confirmed on a large scale, HLA typing may serve as a useful indication of interferon-therapy responders.

Publication types

Clinical Trial
Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Child
Genes, MHC Class I*
HLA-B35 Antigen / analysis*
Hepatitis B / immunology
Hepatitis B / therapy*
Hepatitis, Chronic / immunology
Hepatitis, Chronic / therapy*
Humans
Interferon-alpha / therapeutic use*

Substances

HLA-B35 Antigen
Interferon-alpha