Titanocene(III)-promoted Reformatsky additions

Org Lett. 2003 Oct 2;5(20):3615-7. doi: 10.1021/ol035269c.

Abstract

[reaction: see text] A novel method for the promotion of Reformatsky-like reactions is presented. The technique employs titanocene(III) chloride as a mild and homogeneous single-electron reductant. The reactions are rapid, operationally simple, and compatible with a wide range of functionalities. These additions are also anti diastereoselective.