Abstract
The aim of this study was to assess the influence of aspirin on selected inflammatory markers in patients recovering from acute myocardial infarction (AMI). Patients participating in the Warfarin Aspirin Re-Infarction Study-II were randomized to either aspirin 160 mg/day or aspirin 75 mg/day + warfarin, or warfarin alone after AMI. After AMI, aspirin 160 mg/day was associated with significantly lower levels of high-sensitivity C-reactive protein and tumor necrosis factor-alpha than warfarin alone over 4 years. However, the same levels were not predictors for clinical end points.
Publication types
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Clinical Trial
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Comparative Study
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Multicenter Study
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Randomized Controlled Trial
MeSH terms
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Adult
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Aged
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
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Anticoagulants / therapeutic use
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Aspirin / therapeutic use*
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Biomarkers / blood
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C-Reactive Protein / drug effects
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Drug Therapy, Combination
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Female
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Follow-Up Studies
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Humans
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Inflammation / blood*
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Inflammation / complications
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Inflammation / drug therapy*
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Interleukin-10 / blood
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Interleukin-6 / blood
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Male
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Middle Aged
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Myocardial Infarction / drug therapy*
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Myocardial Infarction / etiology
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Myocardial Infarction / metabolism
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Time
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Tumor Necrosis Factor-alpha / drug effects
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Warfarin / therapeutic use
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Anticoagulants
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Biomarkers
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Interleukin-6
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Tumor Necrosis Factor-alpha
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Interleukin-10
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Warfarin
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C-Reactive Protein
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Aspirin