Abstract
Concepts regarding the function of the hyperpolarization-activated current (Ih) in shaping the excitability of single cells and neuronal ensembles have been evolving rapidly following the recent cloning of genes that encode the underlying 'h-channels' - the HCN genes. This article reviews new information about the transcriptional regulation of these channels, highlighting novel studies that demonstrate short- and long-term modulation of HCN expression, and linking this modulation to mechanisms of neurological diseases.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
-
Review
MeSH terms
-
Animals
-
Cyclic Nucleotide-Gated Cation Channels
-
Gene Expression Regulation
-
Humans
-
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
-
Ion Channels / chemistry
-
Ion Channels / genetics*
-
Ion Channels / metabolism*
-
Ion Channels / physiology
-
Membrane Potentials
-
Nerve Tissue Proteins / genetics*
-
Nerve Tissue Proteins / metabolism*
-
Nervous System Diseases / metabolism
-
Neurons / metabolism
-
Neurons / physiology*
-
Potassium Channels
-
Transcription, Genetic
Substances
-
Cyclic Nucleotide-Gated Cation Channels
-
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
-
Ion Channels
-
Nerve Tissue Proteins
-
Potassium Channels