Abstract
Five alkaloids have been isolated from a New Caledonian sponge Xestospongia sp. These include three known xestospongin derivatives, the new demethylxestospongin B (1) and a tetrahydrocarboline derivative 5. The structures of the new compounds 1 and 5 have been established by nmr studies and comparison with previously described products.
MeSH terms
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Animals
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Antineoplastic Agents / pharmacology*
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Humans
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KB Cells / drug effects
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Leukemia L1210 / drug therapy
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Leukemia P388 / drug therapy
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Macrocyclic Compounds
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Magnetic Resonance Spectroscopy
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Oxazoles
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Porifera / chemistry*
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Tumor Cells, Cultured
Substances
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Alkaloids
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Antineoplastic Agents
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Macrocyclic Compounds
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Oxazoles
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demethylxestospongine B
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xestospongin B