Abstract
To study the growing trend of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae in pediatric intensive care units (PICUs), 88 nonrepetitive ESBL-producing isolates were prospectively collected and analyzed by molecular methods during a 16-month period. The emergence and dissemination of ESBL-producing Enterobacteriaceae in PICUs are the consequence of the clonal dissemination of a few epidemic strains along with the horizontal transmission of resistance gene-carrying plasmids among bacterial organisms.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Anti-Bacterial Agents / pharmacology
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Cefotaxime / pharmacology
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Ceftazidime / pharmacology
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Cephalosporin Resistance
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Child
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Child, Preschool
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Enterobacteriaceae / drug effects
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Enterobacteriaceae / enzymology*
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Enterobacteriaceae / genetics
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Enterobacteriaceae Infections / microbiology
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Humans
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Intensive Care Units, Pediatric*
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Microbial Sensitivity Tests
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Polymerase Chain Reaction / methods
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beta-Lactamases / genetics*
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beta-Lactamases / metabolism
Substances
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Anti-Bacterial Agents
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Ceftazidime
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beta-Lactamases
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Cefotaxime