[Upper mesenteric venous thrombosis revealing familial resistance to activated protein C]

Presse Med. 2003 Oct 4;32(32):1505-6.
[Article in French]

Abstract

Introduction: Mesenteric venous thrombosis is a rare disease but potentially severe because of the prognosis of intestinal infarction with high mortality rate (60%).

Observation: We report the case of a 55 year-old man who presented with an upper mesenteric venous thrombosis related to a familial resistance to C reactive protein through factor V Leiden mutation.

Comments: The discovery of a mesenteric venous thrombosis requires aetiological research that is usually multifactorial. Among the most frequent genetic coagulation abnormalities observed resistance to C reactive protein due to G202110A prothrombin gene mutation is the most common. Although factor V Leiden mutation is less frequent, it requires anticoagulation therapy for life in the case of the appearance of a thrombosis.

Publication types

  • Case Reports

MeSH terms

  • Activated Protein C Resistance / diagnosis
  • Activated Protein C Resistance / genetics*
  • Disease Progression
  • Factor V / genetics*
  • Genetic Carrier Screening
  • Heparin / administration & dosage
  • Humans
  • Infarction / diagnosis
  • Infarction / genetics
  • Infarction / surgery
  • Intestine, Small / blood supply
  • Male
  • Mesenteric Vascular Occlusion / diagnosis
  • Mesenteric Vascular Occlusion / genetics*
  • Mesenteric Vascular Occlusion / surgery
  • Mesenteric Veins
  • Middle Aged
  • Mutation / genetics*
  • Thrombosis / diagnosis
  • Thrombosis / genetics*
  • Thrombosis / surgery
  • Tomography, X-Ray Computed

Substances

  • factor V Leiden
  • Factor V
  • Heparin