Synthesis of beta-substituted cationic porphyrins and their interactions with DNA

Bo Chen; Wen Qin; Ping Wang; Tian Tian; Hongjuan Ma; Xiaoping Cao; Xiaojun Wu; Xiang Zhou; Xiao-Lian Zhang; Fang Liu; Fang Zheng; Xia Li

doi:10.1016/j.bmcl.2003.08.016

Synthesis of beta-substituted cationic porphyrins and their interactions with DNA

Bioorg Med Chem Lett. 2003 Nov 3;13(21):3731-3. doi: 10.1016/j.bmcl.2003.08.016.

Authors

Bo Chen¹, Wen Qin, Ping Wang, Tian Tian, Hongjuan Ma, Xiaoping Cao, Xiaojun Wu, Xiang Zhou, Xiao-Lian Zhang, Fang Liu, Fang Zheng, Xia Li

Affiliation

¹ College of Chemistry and Molecular Sciences, Wuhan University, Hubei Wuhan 430072, P.R. China.

PMID: 14552768
DOI: 10.1016/j.bmcl.2003.08.016

Abstract

The beta-substituted cationic porphyrins (7, 8 and 10) have been synthesized and their interactions with plasmid DNA investigated. We found that substituents at the beta-position of porphyrins (7 and 8) have apparently affected their interactions with DNA compared with non-beta-substituted porphyrins (10).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Absorption
Cations
DNA / drug effects*
DNA Damage
Electrophoresis, Agar Gel
Photochemistry
Plasmids / drug effects
Porphyrins / chemical synthesis*
Porphyrins / chemistry
Porphyrins / pharmacology*
Structure-Activity Relationship

Substances

Cations
Porphyrins
DNA