New benzylidenethiazolidinediones as antibacterial agents

Bioorg Med Chem Lett. 2003 Nov 3;13(21):3771-3. doi: 10.1016/j.bmcl.2003.07.010.

Abstract

A novel benzylidenethiazolidinedione has been discovered with antimicrobial activity. Here, we present the results of a structure-activity study on this compound with respect to its antimicrobial activity.

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / pharmacology*
  • Benzyl Compounds / chemical synthesis*
  • Benzyl Compounds / pharmacology*
  • Enterococcus faecalis / drug effects
  • Gram-Negative Bacteria / drug effects
  • Indicators and Reagents
  • Microbial Sensitivity Tests
  • Staphylococcus aureus / drug effects
  • Streptococcus pneumoniae / drug effects
  • Structure-Activity Relationship
  • Thiazolidinediones / chemical synthesis*
  • Thiazolidinediones / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Benzyl Compounds
  • Indicators and Reagents
  • Thiazolidinediones