Comprehensive step-by-step engineering of an (R)-hydroxynitrile lyase for large-scale asymmetric synthesis

Angew Chem Int Ed Engl. 2003 Oct 13;42(39):4815-8. doi: 10.1002/anie.200352141.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetonitriles / chemistry
  • Chlorine / chemistry
  • Glycosylation
  • Hydro-Lyases / chemical synthesis*
  • Models, Molecular
  • Mutagenesis, Site-Directed
  • Nitriles / chemical synthesis
  • Pichia
  • Saccharomyces cerevisiae

Substances

  • Acetonitriles
  • Nitriles
  • cyanohydrin
  • Chlorine
  • mandelonitrile
  • Hydro-Lyases
  • nitrile hydratase