The novel gluconeogenesis inhibitors FR225659 and related compounds that originate from Helicomyces sp. No. 19353. II. Biological profiles

Yoshihiro Ohtsu; Hiromi Sasamura; Toshihiro Shibata; Hidenori Nakajima; Motohiro Hino; Takashi Fujii

doi:10.7164/antibiotics.56.689

The novel gluconeogenesis inhibitors FR225659 and related compounds that originate from Helicomyces sp. No. 19353. II. Biological profiles

J Antibiot (Tokyo). 2003 Aug;56(8):689-93. doi: 10.7164/antibiotics.56.689.

Authors

Yoshihiro Ohtsu¹, Hiromi Sasamura, Toshihiro Shibata, Hidenori Nakajima, Motohiro Hino, Takashi Fujii

Affiliation

¹ Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 5-2-3 Tokodai, Tsukuba, Ibaraki 300-2698, Japan. [email protected]

PMID: 14563157
DOI: 10.7164/antibiotics.56.689

Abstract

The novel gluconeogenesis inhibitor FR225659 and four related compounds were isolated from the cultured broth of a fungal strain No. 19353. These compounds inhibited the glucagon-stimulated gluconeogenesis of rat primary hepatocytes and had hypoglycemic effects in two different in vivo models.

MeSH terms

Animals
Cells, Cultured
Female
Gluconeogenesis / drug effects*
Hepatocytes* / drug effects
Hepatocytes* / metabolism
Hyperglycemia / prevention & control*
Hypoglycemic Agents / isolation & purification
Hypoglycemic Agents / pharmacology*
Hypoglycemic Agents / therapeutic use
Mice
Rats

Substances

Hypoglycemic Agents