Dinucleoside polyphosphate NAD analogs as potential NMN adenylyltransferase inhibitors. Synthesis and biological evaluation

P Franchetti; L Cappellacci; M Pasqualini; M Grifantini; T Lorenzi; N Raffaelli; G Magni

doi:10.1081/NCN-120022673

Dinucleoside polyphosphate NAD analogs as potential NMN adenylyltransferase inhibitors. Synthesis and biological evaluation

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):865-8. doi: 10.1081/NCN-120022673.

Authors

P Franchetti¹, L Cappellacci, M Pasqualini, M Grifantini, T Lorenzi, N Raffaelli, G Magni

Affiliation

¹ Department of Chemical Sciences, University of Camerino, Camerino, Italy. [email protected]

PMID: 14565298
DOI: 10.1081/NCN-120022673

Abstract

Two dinucleoside polyphosphate NAD analogs, P1-(adenosine-5')-P3-(nicotinamide riboside-5')triphosphate (Np3A, 1) and P1-(adenosine-5')-P4-(nicotinamide riboside-5')tetraphosphate (Np4A, 2), were synthesized and tested as inhibitors of both microbial and human recombinant NMN adenylyltransferase. Compounds 1 and 2 proved to be selective inhibitors of microbial enzymes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Enzyme Inhibitors / chemical synthesis*
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology
Humans
NAD / analogs & derivatives*
NAD / chemical synthesis*
NAD / chemistry
NAD / pharmacology
Nicotinamide-Nucleotide Adenylyltransferase / antagonists & inhibitors*
Recombinant Proteins / antagonists & inhibitors

Substances

Enzyme Inhibitors
Recombinant Proteins
NAD
Nicotinamide-Nucleotide Adenylyltransferase