A new tiazofurin pronucleotide: synthesis and biological evaluation of cyclosaligenyl-tiazofurin monophosphate

L Cappellacci; G Barboni; P Franchetti; C Martini; H N Jayaram; M Grifantini

doi:10.1081/NCN-120022674

A new tiazofurin pronucleotide: synthesis and biological evaluation of cyclosaligenyl-tiazofurin monophosphate

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):869-72. doi: 10.1081/NCN-120022674.

Authors

L Cappellacci¹, G Barboni, P Franchetti, C Martini, H N Jayaram, M Grifantini

Affiliation

¹ Department of Chemical Sciences, University of Camerino, Camerino, MC, Italy.

PMID: 14565299
DOI: 10.1081/NCN-120022674

Abstract

Synthesis and biological activities of cyclosaligenyl-tiazofurin monophosphate (CycloSal-TRMP), a new tiazofurin pronucleotide, are reported. CycloSal-TRMP proved to be active in vitro against human myelogenous leukemia K562 cell line and as A1 adenosine receptor agonist.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenosine A1 Receptor Antagonists
Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / pharmacology
Cell Survival / drug effects
Humans
K562 Cells
Phosphates / chemical synthesis
Phosphates / pharmacology
Prodrugs / chemical synthesis*
Prodrugs / pharmacology
Ribavirin / analogs & derivatives*
Ribavirin / chemical synthesis*
Ribavirin / pharmacology

Substances

Adenosine A1 Receptor Antagonists
Antineoplastic Agents
Phosphates
Prodrugs
Ribavirin
tiazofurin