Design and synthesis of A3 adenosine receptor ligands, 2'-fluoro analogues of Cl-IB-MECA

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):927-30. doi: 10.1081/NCN-120022687.

Abstract

Synthesis of 2'-deoxy-2'-fluoro-N6-substituted adenosines as bioisosteres of Cl-IB-MECA and their binding affinities to A3 adenosine receptor are described.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine / analogs & derivatives*
  • Adenosine / chemical synthesis
  • Adenosine / chemistry
  • Adenosine / pharmacokinetics*
  • Animals
  • Brain / metabolism
  • Drug Design
  • Fluorides
  • Humans
  • Ligands
  • Rats
  • Receptor, Adenosine A3 / metabolism*

Substances

  • Ligands
  • Receptor, Adenosine A3
  • Adenosine
  • Fluorides
  • 2-chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide