xylo-configured oligonucleotides (XNA, xylo nucleic acids): synthesis and hybridization studies

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1147-9. doi: 10.1081/NCN-120022822.

Abstract

We report synthesis and high-affinity hybridization of fully modified home-thymine 2'-deoxy and 2'-deoxy-2'-fluoro xylo nucleic acids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • DNA, Complementary / chemistry
  • Nucleic Acid Hybridization
  • Oligonucleotides / chemical synthesis*
  • Oligonucleotides / chemistry*
  • RNA, Complementary / chemistry
  • Thymine
  • Xylose*

Substances

  • DNA, Complementary
  • Oligonucleotides
  • RNA, Complementary
  • Xylose
  • Thymine