Abstract
Alpha-ODNs conjugated to imidazole groups via phosphoramidate internucleosidic linkages were synthesized. The presence of the imidazolethyl-phosphoramidate linkage improved the affinity of alpha-ODNs for their nucleic acid targets.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amides*
-
Base Sequence
-
Binding Sites
-
Imidazoles*
-
Nucleic Acid Hybridization
-
Oligodeoxyribonucleotides / chemical synthesis*
-
Oligodeoxyribonucleotides / chemistry
-
Phosphoric Acids*
Substances
-
Amides
-
Imidazoles
-
Oligodeoxyribonucleotides
-
Phosphoric Acids
-
phosphoramidic acid