Abstract
An efficient synthesis of adenosine bearing pyrrolepolyamide 1 was achieved by coupling of 3 with 2. The CD spectra obtained at several [ligand ]/[duplex] ratios allowed verification of the formation complex of the DNA duplex [d(CGCAAATTGGC)/d(GCCAATTTGCG)] with 1.
MeSH terms
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Circular Dichroism
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DNA / chemistry*
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Models, Molecular
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Nucleic Acid Conformation
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Nucleic Acid Hybridization
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Nucleosides / chemical synthesis*
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Nucleosides / chemistry
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Nylons
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Oligodeoxyribonucleotides / chemical synthesis*
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Oligodeoxyribonucleotides / chemistry
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Pyrroles
Substances
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Nucleosides
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Nylons
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Oligodeoxyribonucleotides
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Pyrroles
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DNA