Abstract
Unilateral intracarotid injection of contrast agents may considerably destabilize the blood-brain barrier in rats. This leads to vasogenic edema in the ipsilateral hemisphere. Mortality and extravasation increased significantly when administration of these ultrasound contrast agents was followed by mild traumatic brain injury. Direct administration to the cerebral circulation is, therefore, indicative for edema-related pathology and may amplify the consequences of experimental neurotrauma.
MeSH terms
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Albumins / administration & dosage
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Albumins / adverse effects
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Albumins / pharmacokinetics
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Animals
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Blood-Brain Barrier / drug effects*
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Brain Edema / etiology
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Brain Edema / pathology
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Brain Injuries / pathology*
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Contrast Media / administration & dosage
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Contrast Media / adverse effects*
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Contrast Media / pharmacokinetics
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Disease Models, Animal
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Dose-Response Relationship, Drug
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Extravasation of Diagnostic and Therapeutic Materials / pathology*
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Fluorocarbons / administration & dosage
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Fluorocarbons / adverse effects
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Fluorocarbons / pharmacokinetics
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Functional Laterality
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Injections, Intra-Arterial
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Male
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Nerve Degeneration / etiology*
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Nerve Degeneration / pathology
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Polysaccharides / administration & dosage
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Polysaccharides / adverse effects
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Polysaccharides / pharmacokinetics
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Rats
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Ultrasonography
Substances
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Albumins
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Contrast Media
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FS 069
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Fluorocarbons
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Polysaccharides
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SHU 508