Metastases from melanoma to biliary ducts are little known but not so rare, although only a few cases have been previously described. A case of metastasis from amelanotic melanoma to the common bile duct, appearing as a vegetating lesion and diagnosed by spiral computed tomography, using also computed tomography virtual cholangioscopy, is described. The clinical role of computed tomography virtual cholangioscopy is discussed. Metastases from melanoma are recommended to be considered in differential diagnosis of endoluminal soft masses in the biliary ducts.