Abstract
Here, we have investigated the mRNA expression of Toll-like receptor 2 (TLR-2), TLR-4, and MD-2 in spleens and livers of C3H/HeN mice (carrying wild-type TLR-4) and C3H/HeJ mice (carrying mutated TLR-4) in response to Salmonella infection. During Salmonella infections, TLR-4 is activated, leading to increased TLR-2 and decreased TLR-4 expression.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Gene Expression Regulation
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Liver / pathology
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Macrophages / physiology
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Membrane Glycoproteins / genetics
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Membrane Glycoproteins / physiology*
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Mice
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Mice, Inbred C3H
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Neutrophils / physiology
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Receptors, Cell Surface / genetics
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Receptors, Cell Surface / physiology*
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Salmonella Infections, Animal / immunology
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Salmonella Infections, Animal / metabolism*
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Salmonella Infections, Animal / pathology
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Salmonella typhimurium / growth & development
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Spleen / pathology
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Toll-Like Receptor 2
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Toll-Like Receptor 4
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Toll-Like Receptors
Substances
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Membrane Glycoproteins
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Receptors, Cell Surface
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Toll-Like Receptor 2
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Toll-Like Receptor 4
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Toll-Like Receptors