Pathologically confirmed corticobasal degeneration presenting with visuospatial dysfunction

Neurology. 2003 Oct 28;61(8):1134-5. doi: 10.1212/01.wnl.0000086814.35352.b3.

Abstract

Corticobasal degeneration (CBD) typically manifests as progressive asymmetric rigidity and apraxia, although other non-motor presentations have been reported. We report two patients with pathologically diagnosed CBD who presented with prominent visuospatial dysfunction. The pathological changes were maximal in the visual association cortices, but absent in 31 cases of pathologically proven CBD with more typical antemortem features. Underlying CBD should be considered in the differential diagnosis of patients with findings reflecting posterior cerebral dysfunction.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Agraphia / etiology
  • Apraxias / etiology
  • Brain / pathology
  • Disease Progression
  • Dyslexia / etiology
  • Fatal Outcome
  • Female
  • Gerstmann Syndrome / etiology*
  • Humans
  • Male
  • Middle Aged
  • Neurodegenerative Diseases / complications*
  • Neurodegenerative Diseases / diagnosis*
  • Neurodegenerative Diseases / physiopathology
  • Neurologic Examination
  • Neuropsychological Tests
  • Parkinsonian Disorders / etiology
  • Vision Disorders / etiology*