Treatment of glioblastoma multiforme in the elderly in functionally non-critical areas. Clinical remarks on 22 patients

J Exp Clin Cancer Res. 2003 Sep;22(3):395-8.

Abstract

The aim of this study was to evaluate the efficacy of multimodality treatment of glioblastoma multiforme in the elderly. Although several studies report a poor outcome in elderly patients with glioblastoma, in the light of our experience, treatment of elderly patients with glioblastoma in non-critical areas and Karnofsky Performance Status > 60 should be just as aggressive as in younger patients.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Brain Neoplasms / drug therapy
  • Brain Neoplasms / radiotherapy
  • Brain Neoplasms / surgery
  • Brain Neoplasms / therapy*
  • Dacarbazine / analogs & derivatives*
  • Dacarbazine / therapeutic use
  • Female
  • Glioblastoma / drug therapy
  • Glioblastoma / radiotherapy
  • Glioblastoma / surgery
  • Glioblastoma / therapy*
  • Humans
  • Male
  • Neoplasm Recurrence, Local
  • Neoplasm, Residual
  • Survival Rate
  • Temozolomide

Substances

  • Dacarbazine
  • Temozolomide