Simultaneous in vitro assay of the first four enzymes in the fungal aspartate pathway identifies a new class of aspartate kinase inhibitor

Chem Biol. 2003 Oct;10(10):967-73. doi: 10.1016/j.chembiol.2003.09.016.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetyltransferases / analysis
  • Acetyltransferases / metabolism
  • Aminobutyrates / pharmacology
  • Aminolevulinic Acid / analogs & derivatives
  • Aminolevulinic Acid / pharmacology
  • Antifungal Agents / pharmacology*
  • Aspartate Kinase / analysis
  • Aspartate Kinase / antagonists & inhibitors*
  • Aspartate Kinase / metabolism
  • Aspartate-Semialdehyde Dehydrogenase / analysis
  • Aspartate-Semialdehyde Dehydrogenase / metabolism
  • Aspartic Acid / metabolism*
  • Binding Sites
  • Enzyme Inhibitors / pharmacology*
  • Homoserine Dehydrogenase / analysis
  • Homoserine Dehydrogenase / metabolism
  • Kinetics
  • Oligopeptides / pharmacology
  • Organophosphorus Compounds / pharmacology
  • Saccharomyces cerevisiae / enzymology*
  • Structure-Activity Relationship
  • Substrate Specificity

Substances

  • Aminobutyrates
  • Antifungal Agents
  • Enzyme Inhibitors
  • Oligopeptides
  • Organophosphorus Compounds
  • rhizocticin A
  • azoxybacilin
  • Aspartic Acid
  • 2-amino-5-hydroxy-4-oxopentanoic acid
  • Aminolevulinic Acid
  • Homoserine Dehydrogenase
  • Aspartate-Semialdehyde Dehydrogenase
  • Acetyltransferases
  • homoserine O-acetyltransferase
  • Aspartate Kinase