NACP-REP1 polymorphism is not involved in Parkinson's disease: a case-control study in a population sample from southern Italy

P Spadafora; G Annesi; A A Pasqua; P Serra; I C Cirò Candiano; S Carrideo; P Tarantino; D Civitelli; E V De Marco; G Nicoletti; F Annesi; A Quattrone

doi:10.1016/s0304-3940(03)00859-0

NACP-REP1 polymorphism is not involved in Parkinson's disease: a case-control study in a population sample from southern Italy

Neurosci Lett. 2003 Nov 13;351(2):75-8. doi: 10.1016/s0304-3940(03)00859-0.

Authors

P Spadafora¹, G Annesi, A A Pasqua, P Serra, I C Cirò Candiano, S Carrideo, P Tarantino, D Civitelli, E V De Marco, G Nicoletti, F Annesi, A Quattrone

Affiliation

¹ Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy.

PMID: 14583385
DOI: 10.1016/s0304-3940(03)00859-0

Abstract

Contradictory evidence has been reported on the role of the polymorphic mixed dinucleotide repeat (NACP-REP1) of the alpha-synuclein gene as a risk factor for sporadic Parkinson's disease (PD). In the present study we genotyped the NACP-REP1 polymorphism in 189 PD patients from southern Italy and 182 healthy control subjects. We failed to demonstrate an association of any NACP-REP1 allele with PD.

MeSH terms

Aged
Aged, 80 and over
Case-Control Studies
Dinucleotide Repeats / genetics*
Female
Gene Frequency / genetics
Genetic Predisposition to Disease / genetics
Genetic Testing
Genotype
Humans
Italy / epidemiology
Male
Middle Aged
Nerve Tissue Proteins / biosynthesis
Nerve Tissue Proteins / genetics*
Parkinson Disease / epidemiology
Parkinson Disease / genetics*
Polymorphism, Genetic / genetics*
Synucleins
alpha-Synuclein

Substances

Nerve Tissue Proteins
SNCA protein, human
Synucleins
alpha-Synuclein