[Simultaneous detection of both non-Hodgkin's lymphoma cells and breast cancer cells in pleural effusion--a case report]

Eijiro Nagasaki; Noriyuki Furuta; Eiji Shinozaki; Nahomi Tokutome; Yuko Mishima; Keisho Chin; Yasuhito Terui; Nobuyuki Mizunuma; Shunji Takahashi; Yoshinori Itoh; Noriko Usui; Kiyohiko Hatake

[Simultaneous detection of both non-Hodgkin's lymphoma cells and breast cancer cells in pleural effusion--a case report]

Gan To Kagaku Ryoho. 2003 Oct;30(10):1523-7.

[Article in Japanese]

Authors

Eijiro Nagasaki¹, Noriyuki Furuta, Eiji Shinozaki, Nahomi Tokutome, Yuko Mishima, Keisho Chin, Yasuhito Terui, Nobuyuki Mizunuma, Shunji Takahashi, Yoshinori Itoh, Noriko Usui, Kiyohiko Hatake

Affiliation

¹ Dept. of Medical Oncology, Cancer Institute Hospital.

PMID: 14584290

Abstract

A 55-year-old woman underwent breast-conserving surgery with irradiation for Stage IIB (T2 N1 M0) breast cancer of her right breast. Thereafter, she was treated orally with oral UFT and tamoxifen. Three years following surgery, she was diagnosed as having a non-Hodgkin's lymphoma. She underwent 6 cycles of EPOCH-G (etoposide, vincristine, adriamycin, cyclophosphamide, prednisolone, G-CSF) therapy, and obtained complete remission. Two years later, her neck and inguinal lymph nodes were swollen. Biopsy confirmed the relapse of NHL. She underwent salvage chemotherapies of MST-16, carboplatin, IVAC, and CPT-11, but the disease was refractory. In May 2000, bilateral pleural effusion was detected. Cytomorphologically, the pleural fluid specimen showed both atypical lymphoid cells and adenocarcinoma cells simultaneously. Existence of double cancer in the pleural effusion has not been reported, suggesting that this case is rare.

Publication types

Case Reports
English Abstract

MeSH terms

Adenocarcinoma / drug therapy
Adenocarcinoma / pathology*
Adenocarcinoma / surgery
Antineoplastic Combined Chemotherapy Protocols / administration & dosage
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Breast Neoplasms / drug therapy
Breast Neoplasms / pathology*
Breast Neoplasms / surgery
Cyclophosphamide / administration & dosage
Doxorubicin / administration & dosage
Drug Combinations
Etoposide / administration & dosage
Female
Granulocyte Colony-Stimulating Factor / administration & dosage
Humans
Lymphoma, Non-Hodgkin / drug therapy
Lymphoma, Non-Hodgkin / pathology*
Mastectomy, Segmental
Middle Aged
Neoplasm Recurrence, Local / pathology
Neoplasms, Second Primary / pathology*
Pleural Effusion / pathology*
Prednisone / administration & dosage
Tamoxifen / administration & dosage
Tegafur / administration & dosage
Uracil / administration & dosage
Vincristine / administration & dosage

Substances

Drug Combinations
UFT(R) drug
Tamoxifen
Granulocyte Colony-Stimulating Factor
Tegafur
Uracil
Vincristine
Etoposide
Doxorubicin
Cyclophosphamide
Prednisone

Supplementary concepts

EPOCH protocol