Fetal bovine serum, but not human serum, inhibits the in vitro cytotoxicity of ET-743 (Yondelis, trabectedin), an example of potential problems for extrapolation of active drug concentrations from in vitro studies

Cancer Chemother Pharmacol. 2004 Jan;53(1):89-90. doi: 10.1007/s00280-003-0704-y. Epub 2003 Oct 28.
No abstract available

MeSH terms

  • Animals
  • Antineoplastic Agents, Alkylating / pharmacology*
  • Cattle
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Culture Media
  • Dioxoles / pharmacology*
  • Female
  • Humans
  • Isoquinolines / pharmacology*
  • Ovarian Neoplasms / pathology
  • Serum / chemistry*
  • Tetrahydroisoquinolines
  • Trabectedin

Substances

  • Antineoplastic Agents, Alkylating
  • Culture Media
  • Dioxoles
  • Isoquinolines
  • Tetrahydroisoquinolines
  • Trabectedin