Abstract
Shell cross-linked nanoparticles (SCKs) constitute a unique class of materials with amphiphilic core-shell morphology; SCKs are characterised by their structural integrity and available functionality to attach receptor-recognising or receptor-specific ligands on the shell surface and, therefore, hold great potential in drug delivery applications; in an attempt to develop novel, cancer cell specific delivery vehicles, folate receptor targeted SCKs have been prepared.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacokinetics
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Carrier Proteins / metabolism*
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Drug Delivery Systems / methods*
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Drug Design*
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Folate Receptors, GPI-Anchored
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Folic Acid / chemistry*
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Folic Acid / pharmacokinetics
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Humans
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Ligands
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Molecular Structure
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Nanotechnology
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Polyethylene Glycols / chemistry
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Polyethylene Glycols / pharmacokinetics
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Receptors, Cell Surface / metabolism*
Substances
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Antineoplastic Agents
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Carrier Proteins
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Folate Receptors, GPI-Anchored
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Ligands
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Receptors, Cell Surface
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Polyethylene Glycols
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Folic Acid