Naringenin derivatives as anti-atherogenic agents

Bioorg Med Chem Lett. 2003 Nov 17;13(22):3901-3. doi: 10.1016/j.bmcl.2003.09.009.

Abstract

Two classes of naringenin derivatives were evaluated for anti-atherogenic activity. Naringenin 7-O-oleic ester (2) and naringenin 7-O-cetyl ether (3) inhibited the formation of aortic atherosclerotic lesions in high cholesterol-fed rabbits.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arteriosclerosis / blood
  • Arteriosclerosis / drug therapy
  • Arteriosclerosis / prevention & control*
  • Diet, Atherogenic
  • Flavanones / therapeutic use*
  • Lipids / blood
  • Rabbits
  • Structure-Activity Relationship

Substances

  • Flavanones
  • Lipids
  • naringenin