Abstract
Tetrapeptide-based peptidomimetic compounds have been shown to effectively inhibit the hepatitis C virus NS3.4A protease without the need of a charged functionality. An aldehyde is used as a prototype reversible electrophilic warhead. The SAR of the P1 and P2 inhibitor positions is discussed.
MeSH terms
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Hepacivirus / drug effects
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Hepacivirus / enzymology*
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Kinetics
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Models, Molecular
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Oligopeptides / chemical synthesis*
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Oligopeptides / pharmacology*
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Protease Inhibitors / chemical synthesis*
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Protease Inhibitors / pharmacology
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Protein Conformation
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Structure-Activity Relationship
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X-Ray Diffraction
Substances
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Oligopeptides
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Protease Inhibitors